Fetal fibronectin test

Last revised by David Luong on 18 Jun 2021

The fetal fibronectin test (fFN) is a test that can be perfomed on a vaginal swab to estimate the risk of preterm labor.

Pathology

fFN is found at the interface of the chorion and the decidua (between the fetal sack and the uterine lining). It can be thought of as an adhesive or "biological glue" that binds the fetal sac to the uterine lining.

While a negative test is generally useful to rule out preterm labor (high negative predictive value), a positive test is not useful to predict the likelihood (low positive predictive value).

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