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A fetal goiter is an enlargement of the thyroid gland in utero. It can occur with either hyper- or hypothyroidism (and in isolated cases of euthyroidism 8).
The mechanism depends on whether the underlying cause is hyper- or hypothyroidism.
- maternal Graves disease with propylthiouracil (PTU) treatment 1
- Pendred syndrome
- polyhydramnios: from impaired swallowing 2
While antenatal detection is rare, once detected, it is important to evaluate fetal thyroid function in order for early treatment to be initiated if necessary.
A fetal goiter may be seen as a relatively homogeneous anterior fetal neck mass. There is also evidence of polyhydramnios. If the goiter is very large the neck may appear hyperextended.
Some investigators have attempted to assess the hyper- or hypothyroid status relying on sonographic features 7:
- hypothyroid goiters
- more likely to have a peripheral vascular pattern on color Doppler
- may have evidence of delayed bone maturation
- may be accompanied by increased fetal movement
- hyperthyroid goiters
- more likely to have central vascularization
- may have evidence of a fetal tachycardia
- may have evidence of advanced bone maturity
Treatment and prognosis
Treatment will, again, depend on whether the fetus is hyper- or hypothyroid.