Fetal hepatosplenomegaly

Fetal hepatosplenomegaly refers to the combined enlargement of both the fetal liver and the fetal spleen.

Pathology

This can occur from a number of pathologies, including:

• transient abnormal myelopoiesis (TAM) ^1,2 associated with trisomy 21
• in association with fetal hydrops
• in utero infections
  • fetal parvovirus B19 infection ⁴
  • fetal rubella infection
  • fetal toxoplasmosis
  • fetal cytomegalovirus infection ⁴
• fetal hypothyroidism ⁵
• due an underlying syndromic association
  • Beckwith-Wiedemann syndrome ³
  • Zellweger syndrome ³
• ​storage disease
  • Gaucher disease
  • Niemann-Pick disease

See also

• fetal hepatomegaly
• fetal splenomegaly