Fetal lung interstitial tumor

Last revised by Hamish Smith on 2 Aug 2021

Fetal lung interstitial tumor (FLIT) is a recently proposed designation for a rare primary lung mass detected prenatally or when the patient is up to 3 months old.

Fetal lung interstitial tumors have a slight predominance in boys 1.

Fetal lung interstitial tumors were first classified by Dishop et al in 2010, after documentation of 10 cases of circumscribed solid to mixed-solid and microcystic lesions with unique pathologic and immunohistologic features distinct from pleuropulmonary blastomas 2.

It can present with varying degrees of respiratory distress, with moderate-to-severe distress developing in infants 1.

Findings on chest radiographs are nonspecific and may include a volume-occupying lobar opacity that displaces the mediastinal structures. Fetal lung interstitial tumors is more characteristically homogeneous and lacks locally aggressive features.

Fetal lung interstitial tumors are low-attenuating masses of uniform attenuation with well-circumscribed margins and no chest wall invasion.

  • T2: hyperintense intrathoracic mass that exerts local mass effect

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