Fetal neuroblastoma

Fetal neuroblastoma is a type of congenital neuroblastoma (neuroblastoma arising in utero).

The estimated incidence is at ~1 in 20,000 births.

In the vast majority (~90%) of cases fetal neuroblastomas arise in the adrenal glands. They have been diagnosed as early as 19 weeks of gestation, but usually are seen in the third trimester (with mean age at diagnosis being ~36 weeks).

Location

There may be a right sided predilection.

Ultrasound

They are typically seen as a complex mass with cystic components (~50% 10) around the expected position of the fetal adrenal gland. Some lesions may appear entirely solid of predominantly cystic.

Colour Doppler interrogation often shows diffuse vascularity rather than a single feeding vessel.

Staging 

Staging is similar to standard neuroblastoma staging.

In almost all cases the tumour undergoes maturation and regression, and prognosis is excellent (in contrast to childhood neuroblastoma) with many institutions recommending conservative management. 

For ultrasound appearances consider:

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Article Information

rID: 13813
System: Obstetrics
Tag: cases
Synonyms or Alternate Spellings:
  • Prenatal neuroblastoma
  • Prenatally diagnosed neuroblastoma
  • In utero neuroblastoma

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