Fibrosing colonopathy a condition characterised by progressive submucosal fibrosis, particularly of the proximal colon. It is associated with high dose lipase supplementation used to treat exocrine insufficiency of the pancreas, such as in treatment for cystic fibrosis.
It is more common in children but has been reported in adults 3. The incidence is thought to have declined from previous decades due to the current use of low dose pancreatic enzyme replacement regimes.
- abdominal pain
- symptoms of obstruction
- long or short segment colon stricture, usually on the right
- the affected colon may be retracted and shortened
- 1. FitzSimmons SC, Burkhart GA, Borowitz D et-al. High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. N. Engl. J. Med. 1997;336 (18): 1283-9. doi:10.1056/NEJM199705013361803 - Pubmed citation
- 2. Fields TM, Michel SJ, Butler CL et-al. Abdominal manifestations of cystic fibrosis in older children and adults. AJR Am J Roentgenol. 2006;187 (5): 1199-203. doi:10.2214/AJR.05.0327 - Pubmed citation
- 3. Brett AS, Mack EH. Fibrosing colonopathy in adults with cystic fibrosis. AJR Am J Roentgenol. 2008;190 (1): W73. doi:10.2214/AJR.06.1589 - Pubmed citation
- 4. Dodge JA. Pancreatic enzymes and Fibrosing Colonopathy. J. Cyst. Fibros. 2015;14 (1): 153. doi:10.1016/j.jcf.2014.09.002 - Pubmed citation