Fibrotic non-specific interstitial pneumonitis
Citation, DOI, disclosures and article data
At the time the article was created Yuranga Weerakkody had no recorded disclosures.View Yuranga Weerakkody's current disclosures
At the time the article was last revised Sebastian Röhrich had the following disclosures:
- contextflow GmbH, Medical advisor (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.View Sebastian Röhrich's current disclosures
Fibrotic non-specific interstitial pneumonitis is a histological subtype of non-specific interstitial pneumonitis (NSIP). It is considered the more common form 1. This pattern manifests as chronic interstitial inflammation obscured by interstitial fibrosis (with dense collagen), a temporal homogeneous pattern, and occasional focal honeycomb fibrosis 3.
Treatment and prognosis
Corticosteroid can be given but it carries a worse prognosis than the cellular type.
The key imaging differential is a UIP pattern
- according to one study 62% of patients with UIP showed subpleural predominance whereas 55% of patients with fibrotic NSIP exhibited random distribution 4