Citation, DOI, disclosures and article data
Citation:
Gaillard F, Knipe H, Yap J, et al. Fluid-fluid level containing bone lesions. Reference article, Radiopaedia.org (Accessed on 25 Mar 2023) https://doi.org/10.53347/rID-7521
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Radiopaedia Events Pty Ltd, Speaker fees (past)
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Fluid-fluid level containing bone lesions are best seen on MRI, although with narrow window width they can also be appreciated on CT.
Epidemiology
Their prevalence is estimated at ~3% of bone and soft tissue tumors 1.
Differential diagnosis
Their presence is non-specific, as they are seen in both benign and malignant lesions:
There is a mnemonic for fluid-fluid levels on MRI.
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- 1. Van Dyck P, Vanhoenacker F, Vogel J et al. Prevalence, Extension and Characteristics of Fluid-Fluid Levels in Bone and Soft Tissue Tumors. Eur Radiol. 2006;16(12):2644-51. doi:10.1007/s00330-006-0250-1 - Pubmed
- 2. A. Mark Davies, Murali Sundaram, Steven J. James. Imaging of Bone Tumors and Tumor-Like Lesions. (2009) ISBN: 9783540779827 - Google Books
- 3. Catalano P, Fang-Hui E, Som P. Fluid-Fluid Levels in Benign Neurogenic Tumors. AJNR Am J Neuroradiol. 1997;18(2):385-7. PMC8338589 - Pubmed
- 4. Williams H, Davies A, Allen G, Evans N, Mangham D. Imaging Features of Intraosseous Ganglia: A Report of 45 Cases. Eur Radiol. 2004;14(10):1761-9. doi:10.1007/s00330-004-2371-8 - Pubmed
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