Focal fibrosis of the breast
Focal fibrosis of the breast (FFB) is a benign entity characterized by abundant connective tissue separating intervening ducts and lobules, which are often atrophic. There is obliteration of the mammary acini and ducts by hypocellular fibrous tissue which results in a localized area of fibrous tissue associated with hypoplastic mammary ducts and lobules.
It can present as a palpable breast mass.
It can have a wide spectrum of imaging findings 3 although most commonly appears as an enlarging solid mass or developing density on mammography or as an oval mass on sonography 1. As it mimics most sinister breast pathology, a biopsy is required to exclude malignancy.
- 1. Rosen EL, Soo MS, Bentley RC. Focal fibrosis: a common breast lesion diagnosed at imaging-guided core biopsy. AJR Am J Roentgenol. 1999;173 (6): 1657-62. AJR Am J Roentgenol (abstract) - Pubmed citation
- 2. Conant EF, Brennecke CM. Breast imaging, case review. Mosby Inc. (2006) ISBN:0323017460. Read it at Google Books - Find it at Amazon
- 3. Revelon G, Sherman ME, Gatewood OM et-al. Focal fibrosis of the breast: imaging characteristics and histopathologic correlation. Radiology. 2000;216 (1): 255-9. Radiology (full text) - Pubmed citation
- 4. You JK, Kim EK, Kwak JY et-al. Focal fibrosis of the breast diagnosed by a sonographically guided core biopsy of nonpalpable lesions: imaging findings and clinical relevance. J Ultrasound Med. 2005;24 (10): 1377-84. J Ultrasound Med (full text) - Pubmed citation
- 5. Venta LA, Wiley EL, Gabriel H et-al. Imaging features of focal breast fibrosis: mammographic-pathologic correlation of noncalcified breast lesions. AJR Am J Roentgenol. 1999;173 (2): 309-16. AJR Am J Roentgenol (abstract) - Pubmed citation