Fournier gangrene is typically seen in diabetic men aged 50-70 years but rarely in women. Other than age, predisposing factors include:
- diabetes mellitus
- perineal/scrotal pain, swelling, redness
- crepitus from soft tissue gas (up to 65%)
- systemically unwell
- fever and leukocytosis
The source of infection can usually be identified, most commonly anorectal (such as from a perianal fistula or abscess) and less commonly genitourinary or perineal trauma. Sometimes the cause is not found.
The infection is usually polymicrobial. The most common organisms cultured are E.coli, Klebsiella, Proteus, Staphylococcus, and Streptococcus.
The diagnosis is usually clinical. The role of imaging includes:
- diagnosis not established
- determine the extent of disease
- detect the underlying cause
Radiolucent soft-tissue gas may be seen in the region overlying the scrotum or perineum. Subcutaneous emphysema may extend from the scrotum and perineum to the inguinal regions, anterior abdominal wall, and thighs.
- thickened scrotal wall
- echogenic gas foci in the scrotum are pathognomonic: seen as dirty shadowing
- testes and epididymides spared (due to their separate blood supply)
- soft tissue stranding, fascial thickening
- soft tissue gas
- the extent of disease can be assessed prior to surgery
- cause of infection may be apparent (e.g. perianal abscess, fistula)
Treatment and prognosis
It is considered a urological emergency with a poor prognosis due to its high mortality rate (ranging ~15-50% 3).
Management options include:
- immediate radical surgical debridement of necrotic tissue
- intravenous antibiotics
- hyperbaric oxygen therapy
- testes replaced into remaining scrotum or covered by skin graft (once infection settled)
History and etymology
It was first described by French professor of dermatology at the University of Paris, and director of the renowned venereal Hospital of St Louis, Jean Alfred Fournier (1832-1914) 6 in 1883. He noted a fulminating gangrenous infection of male genitalia in young healthy males without an obvious cause.
The differential in the setting of acute scrotal pain includes:
- 1. Rajan DK, Scharer KA. Radiology of Fournier's gangrene. AJR Am J Roentgenol. 1998;170 (1): 163-8. AJR Am J Roentgenol (citation) - Pubmed citation
- 2. Uppot RN, Levy HM, Patel PH. Case 54: Fournier gangrene. Radiology. 2003;226 (1): 115-7. doi:10.1148/radiol.2261010714 - Pubmed citation
- 3. Levenson RB, Singh AK, Novelline RA. Fournier gangrene: role of imaging. (2008) Radiographics : a review publication of the Radiological Society of North America, Inc. 28 (2): 519-28. doi:10.1148/rg.282075048 - Pubmed
- 4. Erika Kube, Stanislaw P Stawicki, David P Bahner. Ultrasound in the diagnosis of Fournier's gangrene. (2012) International Journal of Critical Illness and Injury Science. 2 (2): 104. doi:10.4103/2229-5151.97276 - Pubmed
- 5. Marco Di Serafino, Chiara Gullotto, Chiara Gregorini, Claudia Nocentini. A clinical case of Fournier’s gangrene: imaging ultrasound. (2014) Journal of Ultrasound. 17 (4): 303. doi:10.1007/s40477-014-0106-5 - Pubmed
- 6. Haas LF. Jean Alfred Fournier (1832-1914). (1998) Journal of neurology, neurosurgery, and psychiatry. 65 (3): 373. Pubmed