Free/total PSA ratio

Last revised by Daniel J Bell on 16 Oct 2020

The free/total PSA ratio (%fPSA) is an additional new parameter used in assessing prostate specific antigen (PSA) levels. It is the simple mathematical ratio of the free PSA in the serum over the total PSA in the serum and is expressed as a dimensionless quantity 4.

Some authors 1,2 recommend that men with PSA levels of 4.1 to 10 ng/mL who are not suspected of having prostate cancer by whatever means should undergo free/total PSA ratio measurement and then be carefully monitored at short intervals over the long term to see if the ratio declines.

It should be taken into account that free/total PSA ratio will be elevated in men on dialysis treatment 3.

See also

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