Friedrich disease

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Friedrich disease is an eponymous name for osteonecrosis of the sternal end of the clavicle. It is a rare condition and documentation in the medical literature is scarce with most case reports dating from before 1990.

Epidemiology

It is more often encountered in children and adolescents ¹.

Radiographic features

Radiograph and CT

Diffuse sclerosis of the clavicular head of the clavicle is the main finding ^1,2. A central notch-like defect in the centre of sternoclavicular articulation has also been described ¹.

Treatment

It appears to be mostly a self-limited condition that can resolve spontaneously and responds to conservative treatment ^1-3.

Differential diagnosis

The general differentials consideration are those of a sclerotic clavicle.

~~-<p><strong>Friedrich disease</strong> is an eponymous name for <a title="Osteonecrosis" href="/articles/avascular-necrosis">osteonecrosis</a> of the sternal end of the clavicle.</p>~~
+<p><strong>Friedrich disease</strong> is an eponymous name for <a href="/articles/avascular-necrosis">osteonecrosis</a> of the sternal end of the clavicle. It is a rare condition and documentation in the medical literature is scarce with most case reports dating from before 1990.</p><h4>Epidemiology</h4><p>It is more often encountered in children and adolescents <sup>1</sup>.</p><h4>Radiographic features</h4><h5>Radiograph and CT</h5><p>Diffuse sclerosis of the clavicular head of the clavicle is the main finding <sup>1,2</sup>. A central notch-like defect in the centre of sternoclavicular articulation has also been described <sup>1</sup>.</p><h4>Treatment</h4><p>It appears to be mostly a self-limited condition that can resolve spontaneously and responds to conservative treatment <sup>1-3</sup>.</p><h4>Differential diagnosis</h4><p>The general differentials consideration are those of a <a href="/articles/sclerotic-clavicle">sclerotic clavicle</a>.</p>

References changed:

1. RO Cone, D Resnick, TG Goergen, C Robinson, V Vint, P Haghighi. Condensing osteitis of the clavicle. (2012) American Journal of Roentgenology. 141 (2): 387-8. <a href="https://doi.org/10.2214/ajr.141.2.387">doi:10.2214/ajr.141.2.387</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/6603140">Pubmed</a> <span class="ref_v4"></span>
2. Macule F, Ferreres A, Palliso F, Prat S, Ramon R. Aseptic necrosis of the sternal end of the clavicle Friedrich's disease. (1990) Acta orthopaedica Belgica. 56 (3-4): 613-5. <a href="https://www.ncbi.nlm.nih.gov/pubmed/2075818">Pubmed</a> <span class="ref_v4"></span>
3. Shimizu K, Awaya G, Matsuda F, Wakita S, Mayekawa M. Friedrich's disease: a case report. (1991) Nihon geka hokan. Archiv fur japanische Chirurgie. 60 (3): 184-8. <a href="https://www.ncbi.nlm.nih.gov/pubmed/1776913">Pubmed</a> <span class="ref_v4"></span>

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