Frog eye sign

Last revised by Dr Bálint Botz on 27 Apr 2022

The frog eye sign is seen when the orbital structures show a characteristic protrusion due to fetal anencephaly. The term is particularly used in point of care ultrasound (POCUS) 1

Radiographic features

On obstetric ultrasound the frog eye sign is best appreciated in the coronal plane (in relation to the fetal head). The protruding orbital structures is due to the absence of the fetal calvarium and cerebral tissues cephalad to the orbits. This sonographic appearance is best seen from the second trimester 1,2.  

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Cases and figures

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