Fundic gland polyps (FGP) are the most common type of gastric polyp.
FGPs occur most commonly in middle-aged females. They have been reported to be identified in ~1% of gastroscopies 3,4.
FGPs are usually an asymptomatic, incidental finding 1.
FGPs account for ~60% (range 47-77%) of gastric polyps 1-3. They may arise sporadically or be part of the syndrome (e.g. familial adenomatous polyposis), although there are different genetic mutations between sporadic and FAP-associated cases 1,2.
The pathogenesis remains unclear, and there may be an association with antacid medications (e.g. proton pump inhibitors) and reduced rates of Helicobacter pylori infections.
FGPs arise in the gastric body and fundus, and are sessile, measuring <10 mm (normally 1-5 mm) in size. They may be multiple or single 1-4.
Treatment and prognosis
FGPs are benign with no malignant potential 4.
- 1. Spiegel A, Stein P, Patel M et-al. A report of gastric fundic gland polyps. Gastroenterol Hepatol (N Y). 2011;6 (1): 45-8. Free text at pubmed - Pubmed citation
- 2. Torbenson M, Lee JH, Cruz-Correa M et-al. Sporadic fundic gland polyposis: a clinical, histological, and molecular analysis. Mod. Pathol.15 (7): 718-23. doi:doi:10.1097/01.MP.0000018976.15044.9B - Pubmed citation
- 3. Adam B, Pech O, Steckstor M et-al. Video Journal and Encyclopedia of GI Endoscopy. 2013;1 (1): . doi:10.1016/S2212-0971(13)70084-0
- 4. Gore RM, Levine MS. Textbook of Gastrointestinal Radiology: Expert Consult. Saunders. ISBN:B00PQHSMAM. Read it at Google Books - Find it at Amazon
- 5. Radiology Illustrated: Gastrointestinal Tract. Springer. ISBN:B00S16Y3P8. Read it at Google Books - Find it at Amazon