Fundic gland polyp

Last revised by Daniel J Bell on 6 Jan 2022

Fundic gland polyps (FGP) are the most common type of gastric polyp.

Fundic gland polyps occur most commonly in middle-aged females. They have been reported to be identified in ~1% of gastroscopies 3,4

Fundic gland polyps are usually an asymptomatic, incidental finding 1

Fundic gland polyps account for ~60% (range 47-77%) of gastric polyps 1-3. They may arise sporadically or be part of the syndrome (e.g. familial adenomatous polyposis), although there are different genetic mutations between sporadic and FAP-associated cases 1,2

The pathogenesis remains unclear, and there may be an association with antacid medications (e.g. proton pump inhibitors) and reduced rates of Helicobacter pylori infections. 

Fundic gland polyps arise in the gastric body and fundus and are sessile, measuring <10 mm (normally 1-5 mm) in size. They may be multiple or single 1-4.

Sporadic fundic gland polyps are generally regarded as benign. There are case reports of low-grade neoplasia, but no cases of gastric carcinoma 1

Fundic gland polyps associated with FAP demonstrate 41% dysplasia and increase the incidence of gastric carcinoma 1

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