Fundic gland polyps (FGP) are the most common type of gastric polyp.
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Epidemiology
Fundic gland polyps occur most commonly in middle-aged females. They have been reported to be identified in ~1% of gastroscopies 3,4.
Clinical presentation
Fundic gland polyps are usually an asymptomatic, incidental finding 1.
Pathology
Fundic gland polyps account for ~60% (range 47-77%) of gastric polyps 1-3. They may arise sporadically or be part of the syndrome (e.g. familial adenomatous polyposis), although there are different genetic mutations between sporadic and FAP-associated cases 1,2.
The pathogenesis remains unclear, and there may be an association with antacid medications (e.g. proton pump inhibitors) and reduced rates of Helicobacter pylori infections.
Macroscopic appearance
Fundic gland polyps arise in the gastric body and fundus and are sessile, measuring <10 mm (normally 1-5 mm) in size. They may be multiple or single 1-4.
Treatment and prognosis
Sporadic fundic gland polyps are generally regarded as benign. There are case reports of low-grade neoplasia, but no cases of gastric carcinoma 1.
Fundic gland polyps associated with FAP demonstrate 41% dysplasia and increase the incidence of gastric carcinoma 1.