Gadobenate dimeglumine

Dr Dan J Bell and Dr Matt A. Morgan et al.

Gadobenate dimeglumine (also known as MultiHanceTM) is an extracellular intravenous contrast agent used in magnetic resonance imaging.

  • linear, ionic molecule 
  • 95-96% renal excretion, 4-5% hepatic excretion
  • T1 relaxivity @ 1.5 T: 6.0-6.6
  • concentration: 0.5 mmol/ml
  • recommended dosage: 0.1 mmol/kg
Indications

As an extracellular contrast agent, gadobenate dimeglumine can be useful in a wide range of MRI applications, including (but not limited to): hepatic imaging, pelvic imaging, cardiac imaging, brain and spine imaging, and musculoskeletal imaging.

Because it has 4-5% hepatobiliary uptake, it can be used as a hepatobiliary phase agent in some circumstances. The hepatobiliary phase requires a 1 hour delay.

Because of the higher relaxivity than most other extracellular contrast agents, it is preferred in vascular imaging. Gadofosveset trisodium (Ablavar) has approximately 3-4x the relaxivity of gadobenate dimeglumine, but is considered a blood pool agent and its commercial availability is limited.

The high relaxivity of gadobenate dimeglumine also makes it a preferable agent for imaging

Gadobenate dimeglumine has been reported as having a low rate of acute adverse reactions (0.17% rate of total adverse effects with <0.01% serious adverse effects) 2.

Physics and Imaging Technology: MRI
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Article information

rID: 33809
Synonyms or Alternate Spellings:
  • MultiHance

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