Gadobenate dimeglumine

Last revised by Daniel J Bell on 9 Dec 2022

Gadobenate dimeglumine (also known as MultiHance) is an extracellular intravenous contrast agent used in magnetic resonance imaging.

  • linear, ionic molecule 

  • 95-96% renal excretion, 4-5% hepatic excretion

  • T1 relaxivity @ 1.5 T: 6.0-6.6

  • concentration: 0.5 mmol/mL

  • recommended dosage: 0.1 mmol/kg


As an extracellular contrast agent, gadobenate dimeglumine can be useful in a wide range of MRI applications, including (but not limited to): hepatic imaging, pelvic imaging, cardiac imaging, brain and spine imaging, and musculoskeletal imaging.

Because it has 4-5% hepatobiliary uptake, it can be used as a hepatobiliary phase agent in some circumstances but requires a 1-hour delay for imaging acquisition. 

Because of the higher relaxivity than most other extracellular contrast agents, it is preferred in vascular imaging. Gadofosveset trisodium (Ablavar) has approximately 3-4 times the relaxivity of gadobenate dimeglumine but is considered a blood pool agent and its commercial availability is limited.

The high relaxivity of gadobenate dimeglumine also makes it a preferred agent for imaging:

Gadobenate dimeglumine has been reported as having a low rate of acute adverse reactions (0.17% rate of total adverse effects with <0.01% serious adverse effects) 2.

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