Last revised by Daniel J Bell on 9 Dec 2022

Gadoversetamide (also known as OptiMARK) is an extracellular intravenous contrast agent used in magnetic resonance imaging.

  • linear, non-ionic molecule 

  • 100% renally excreted

  • T1 relaxivity at 1.5 T: 4.4-5.0

  • concentration: 0.5 mmol/mL

  • recommended dosage: 0.1 mmol/kg


As an extracellular contrast agent, gadoversetamide can be useful in a wide range of MRI applications, including (but not limited to): hepatic imaging, pelvic imaging, cardiac imaging, brain and spine imaging, and musculoskeletal imaging.


There is an association between the use of gadolinium-based contrast agents (GBCAs) in patients with kidney dysfunction and nephrogenic systemic fibrosis (NSF), a rare, but serious, condition. As a result, the use of three GBCAs; gadoversetamide (OptiMARK), gadopentetate dimeglumine (Magnevist) and gadodiamide (Omniscan) are contraindicated in patients with acute kidney injury or with chronic, severe kidney disease 2.

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