Gain of function
Citation, DOI & article data
Gain of function represents the set of laboratory techniques thanks to which it is possible to genetically modify a pathogen (for example a virus) in order to provide it with new capabilities.The field of application of the gain-of-function, in fact, is virology, in order to improve the understanding of viral genomics and proteomics as well as the variables that affect the virus-host interaction (for example, receptors, vaccines, therapies, etc.)2.
- 1. Selgelid M. Gain-Of-Function Research: Ethical Analysis. Sci Eng Ethics. 2016;22(4):923-64. doi:10.1007/s11948-016-9810-1 - Pubmed
- 2. Board on Life Sciences, Division on Earth and Life Studies, Committee on Science, Technology, and Law et al. Gain-Of-Function Research: Background and Alternatives. National Academies Press (US). 2015. https://www.ncbi.nlm.nih.gov/books/NBK285579/