Gain of function

Last revised by Dr Francesco Sciacca on 24 May 2022

Gain of function represents the set of laboratory techniques thanks to which it is possible to genetically modify a pathogen (for example a virus) in order to provide it with new capabilities.The field of application of the gain-of-function, in fact, is virology, in order to improve the understanding of viral genomics and proteomics as well as the variables that affect the virus-host interaction (for example, receptors, vaccines, therapies, etc.)2.

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