Gain of function
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At the time the article was created Francesco Sciacca had no recorded disclosures.View Francesco Sciacca's current disclosures
At the time the article was last revised Francesco Sciacca had no recorded disclosures.View Francesco Sciacca's current disclosures
Gain of function represents the set of laboratory techniques thanks to which it is possible to genetically modify a pathogen (for example a virus) in order to provide it with new capabilities.The field of application of the gain-of-function, in fact, is virology, in order to improve the understanding of viral genomics and proteomics as well as the variables that affect the virus-host interaction (for example, receptors, vaccines, therapies, etc.)2.
- 1. Selgelid M. Gain-Of-Function Research: Ethical Analysis. Sci Eng Ethics. 2016;22(4):923-64. doi:10.1007/s11948-016-9810-1 - Pubmed
- 2. Board on Life Sciences, Division on Earth and Life Studies, Committee on Science, Technology, and Law et al. Gain-Of-Function Research: Background and Alternatives. National Academies Press (US). 2015. https://www.ncbi.nlm.nih.gov/books/NBK285579/