There is an autosomal dominant inheritance in the tumour suppressor adenomatous polyposis coli (APC) gene (chromosome 5q) in a majority of patients but with 20% of cases resulting from new mutations. Extracolonic features often precede the diagnosis of colonic polyps.
1. Robbins SL, Kumar V, Abbas AK et-al. Robbins and Cotran pathologic basis of disease. W.B. Saunders Company. (2010) ISBN:1416031219. Read it at Google Books - Find it at Amazon
2. Hirokawa M, Manabe T, Hino K. Ampullary carcinoma in Gardner's syndrome: case report. Jpn. J. Clin. Oncol. 1988;18 (1): 43-50. Jpn. J. Clin. Oncol. (link) - Pubmed citation
3. Newman CA, Reuther WL, Wakabayashi MN et-al. Gastrointestinal case of the day. Gardner syndrome. Radiographics. 19 (2): 546-8. Radiographics (full text) - Pubmed citation
4. Wolf J, Järvinen HJ, Hietanen J. Gardner's dento-maxillary stigmas in patients with familial adenomatosis coli. (1986) The British journal of oral & maxillofacial surgery. 24 (6): 410-6. doi:10.1016/0266-4356(86)90054-9 - Pubmed
5. Pereira DL, Carvalho PA, Achatz MI, Rocha A, TardinTorrezan G, Alves FA. Oral and maxillofacial considerations in Gardner's syndrome: a report of two cases. (2016) Ecancermedicalscience. 10: 623. doi:10.3332/ecancer.2016.623 - Pubmed
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