Gardner syndrome
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Gardner syndrome is one of the polyposis syndromes. It is characterized by:
multiple osteomas: especially of the mandible, skull, and long bones
desmoid tumors of mesentery and anterior abdominal wall
Other abnormalities include:
Pathology
There is an autosomal dominant inheritance in the tumor suppressor adenomatous polyposis coli (APC) gene (chromosome 5q) in a majority of patients but with 20% of cases resulting from new mutations. Extracolonic features often precede the diagnosis of colonic polyps.
History and etymology
First described in 1953 by Gardner and Richards 3.
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