Gastrointestinal schwannoma

Gastrointestinal schwannomas are extremely rare mesenchymal neoplasms which arise in relation to the gastrointestinal tract.

They are reported to typically present at about the 3rd to 5th decades of life 4.

Patients are often asymptomatic but may occasionally present with abdominal discomfort or upper gastrointestinal bleeding from overlying mucosal ulceration.

Although they arise from Schwann cells of the gastrointestinal wall neural plexa 4, they are considered to be distinctively different from the conventional schwannomas that arise in soft tissue or the central nervous system in terms of histological features.

  • stomach: 60-70% of cases (commonest location)
  • colon: next commonest location
  • rectum

S100 protein is strongly positive 1,6.

  • typically seen as a well-defined, rounded, mural mass(es) with homogeneous attenuation 2
  • tends to lack cystic change and hemorrhage

Reported features include 4:

  • T1: low or intermediate signal
  • T1 C+ (Gd): may demonstrate slow but relative uniform enhancement
  • T2: high signal

They are benign tumors and carries a much better prognosis compared with gastrointestinal stromal tumors.

Initially reported by Daimaru et al. in 1988 1

Article information

rID: 10659
Tag: cases, cases
Synonyms or Alternate Spellings:
  • Gastrointestinal tract neurinoma
  • Gastrointestinal tract neurilemmoma

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