Gd-DTPA labeled albumin

Last revised by Andrew Murphy on 2 Apr 2020

Gd-DTPA labeled albumin is an intravascular MRI contrast agent. Gd-DTPA is covalently bonded to albumin in ratios from 16:1 to 31:1 providing excellent enhancement of liver, spleen, myocardium, brain, and slow moving blood of rats and rabbits. The albumin has a molecular weight of about 92,000 and a biological half-life of 88 minutes. The dose of Gd-DTPA required when bound to albumin is 0.062 mmol/kg compared to usual doses of the chelate alone of 0.1-0.2 mmol/kg. No adverse reactions are reported, but in vivo retention of the gadolinium for several weeks in liver and bone raises concerns of long term toxicity.

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