Gd-DTPA labelled dextran
Citation, DOI, disclosures and article data
Citation:
Ballinger J, Murphy A, Bell D, et al. Gd-DTPA labelled dextran. Reference article, Radiopaedia.org (Accessed on 29 Mar 2025) https://doi.org/10.53347/rID-21774
rID:
21774
Article created:
17 Feb 2013,
J. Ray Ballinger
Disclosures:
At the time the article was created J. Ray Ballinger had no recorded disclosures.
View J. Ray Ballinger's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Andrew Murphy had no recorded disclosures.
View Andrew Murphy's current disclosures
Revisions:
4 times, by
4 contributors -
see full revision history and disclosures
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Gd-DTPA labelled dextran is an intravascular MRI contrast agent. Dextran is a polysaccharide consisting of a polymer of glucose molecules with a molecular weight between 75,000-100,000. Dextran has a high level of safety and is broken down more rapidly than albumin. Approximately 15 Gd-DTPA molecules are attached to each dextran molecule with an easily hydrolyzable bond. It is hoped that this will reduce the long term in vivo retention seen with Gd-labelled albumin. The trade off is a shorter biological half-life of 43 minutes. In a rat model, satisfactory enhancement of liver, spleen, kidneys, myocardium, and brain is seen for up to 1 hour. The dose of dextran Gd-DTPA in these studies was 0.01-0.05 mmol/kg 1.
A variation of this contrast agent has been commercialized as Riovist (Schering) 2.
References
- 1. Magin RL, Bacic G, Niesman MR et-al. Dextran magnetite as a liver contrast agent. Magn Reson Med. 1991;20 (1): 1-16. Pubmed citation
- 2. Mintorovitch J, Shamsi K. Eovist Injection and Resovist Injection: two new liver-specific contrast agents for MRI. Oncology (Williston Park, N.Y.). 2000;14 (6 Suppl 3): 37-40. Pubmed citation
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