The causes of generalized increase in bone density in adult patients, also known as generalized or diffuse osteosclerosis, can be divided according to broad categories:
- hematological disorders
-
myelosclerosis
- marrow cavity is narrowed by endosteal new bone
- patchy lucencies due to the persistence of fibrous tissue (generalized osteopenia in the early stages due to myelofibrosis)
- hepatosplenomegaly
- sickle cell disease 2
- osteosclerosing multiple myeloma
-
myelosclerosis
- metabolic
- poisoning
-
fluorosis
- with periosteal reaction, prominent muscle attachments and calcification of ligaments and interosseous membranes
- changes are most marked in the innominate bones and lumbar spine
-
fluorosis
- neoplastic (more commonly multifocal than generalized)
- malignancy
- osteoblastic metastases: most commonly prostate and breasts
- lymphoma: infiltrative
- leukemia: infiltrative
-
mastocytosis
- sclerosis of marrow-containing skeleton with patchy areas of radiolucency
- urticaria pigmentosa
- can have symptoms and signs of carcinoid syndrome
- idiopathic (more commonly multifocal than generalized)
- Paget disease: coarsened trabeculae, bony expansion and thickened cortex
- congenital: sclerosing bone dysplasias
- other
A mnemonic for the causes of dense bones is 3 M's PROOF.
