Generalized increased bone density in adults

Last revised by Dr Joshua Yap on 28 Jun 2022

The causes of generalized increase in bone density in adult patients, also known as generalized or diffuse osteosclerosis, can be divided according to broad categories: 

A mnemonic for the causes of dense bones is 3 M's PROOF.

See also

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Cases and figures

  • Case 1: brown tumors with renal osteodystrophy
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  • Case 2: diffuse bone metastases - prostate
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  • Case 3: renal osteodystrophy
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  • Case 4: breast cancer metastasis
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  • Case 5: prostatic carcinoma - osteoblastic metastases
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  • Case 6: systemic mastocytosis
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  • Case 7: Paget disease
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