Ghon lesion
Citation, DOI, disclosures and article data
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosuresAt the time the article was last revised Mostafa Elfeky had no financial relationships to ineligible companies to disclose.
View Mostafa Elfeky's current disclosures- Ghon focus
- Ghon complex
- Ghon foci
- Ghon lesions
- Ghon complexes
- Ghon's lesion
- Ghon's complex
- Ghon's focus
A Ghon lesion, sometimes called a Ghon focus, represents a tuberculous caseating granuloma (tuberculoma) and represents a sequela of primary pulmonary tuberculosis infection.
Terminology
Radiologically, this term is used quite loosely to refer to a calcified granuloma; technically, the Ghon lesion is the initial tuberculous granuloma formed during primary infection and is not radiologically visible unless it calcifies - this occurs in up to 15% of cases 4.
A Ghon focus alongside ipsilateral mediastinal lymphadenopathy is known as a Ghon complex. A calcified Ghon complex (Ghon lesion and ipsilateral mediastinal lymph node) is called a Ranke complex, which is radiologically detectable. Thus the Ranke complex represents a progression of the Ghon complex, rather than being a separate entity in itself 4.
History and etymology
Anton Ghon (1866-1936) was an Austrian pathologist who spent his life researching tuberculosis and meningitis 3.
References
- 1. Collins J, Stern EJ. Chest Radiology. Lippincott Williams & Wilkins. (2008) ISBN:0781763142. Read it at Google Books - Find it at Amazon
- 2. Grainger's and Allison's Diagnostic Radiology. Churchill Livingstone. (2008) ISBN:0443101639. Read it at Google Books - Find it at Amazon
- 3. Ober WB. Ghon but not forgotten: Anton Ghon and his complex. Pathology annual. 18 Pt 2: 79-85. Pubmed
- 4. Joshua Burrill, Christopher J. Williams, Gillian Bain, Gabriel Conder, Andrew L. Hine, Rakesh R. Misra. Tuberculosis: A Radiologic Review1. (2007) RadioGraphics. 27 (5): 1255-73. doi:10.1148/rg.275065176 - Pubmed
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