Glioma treatment response assessment in clinical trials

Last revised by Daniel J Bell on 4 Oct 2021

Glioma treatment response assessment in clinical trials has undergone numerous revisions with a number of criteria having been developed over the years. This has been necessary as a result of a number of factors:

  1. improved understanding of tumor biology (e.g. appreciating the importance of non-enhancing tumor)
  2. the realization that existing criteria are flawed (e.g. measuring necrotic tumors)
  3. changes in imaging parameters

Although superficially most share similarities, as the saying goes, the devil is in the details.

Currently, the most widely used system to assess first line treatment response in glioblastomas (and lower grade diffuse astrocytomas) are the Response Assessment in Neuro-Oncology Criteria (RANO), which were published in 2010 1

To address the challenges of emerging novel immunotherapy for high-grade glioma immunotherapy response assessment for neuro-oncology (iRANO) criteria have been developed in 2015 4.

Previous systems

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