Gluten-related disorders

Last revised by Frank Gaillard on 18 Jul 2019

Gluten-related disorders are a collection of conditions that are the result of a reaction to the consumption of gluten a protein found in wheat, barley and rye 1.

Gluten-related disorders can be broadly divided into 1,2

  1. celiac disease: most common and most widely recognized
  2. wheat allergy
  3. non-celiac gluten sensitivity

Celiac disease is a T-cell mediate autoimmune response to gluten-derived polypeptides resulting in a small bowel enteropathy (see celiac disease article). 

Many non-gastrointestinal manifestations are, however, also recognized including cerebellar ataxia and polyneuropathy 1,2

Wheat allergies are due to IgE antibodies and manifestations will depend on the route of exposure: oral ingestion results in wheat food allergy, inhalation may result in baker's asthma or baker's rhinitis or even a hypersensitivity pneumonitis 2,3.  

This is a poorly defined term but generally refers to the manifestations of a variety of symptoms following gluten exposure that are not, however, immune or allergy-mediated 2.   

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.