Glycogenic acanthosis is a benign finding on oesophagography in elderly patients.
It most commonly occurs in patients >40 years of age and incidence and numbers of lesions increase by age. No gender predilection exists. Typically patients are asymptomatic.
It occurs from a combination of cellular hyperplasia and increased cellular glycogen in squamous epithelial cells lining the oesophagus. The oesophageal mucosa is otherwise normal. It is not thought to be associated with gastro-oesophageal reflux.
Severe forms are seen in patients with Cowden syndrome.
- multiple small nodules and plaques measuring 2-10 mm
- plaques are randomly distributed
- often in the upper to mid thoracic oesophagus
- the appearance can appear similar to other forms of oesophagitis like reflux oesophagitis which however occur more distally and candida oesophagitis which is more linear in configuration
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- 2. Nazligül Y, Aslan M, Esen R et-al. Benign glycogenic acanthosis lesions of the esophagus. Turk J Gastroenterol. 2013;23 (3): 199-202. Pubmed citation
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- oesophageal dysmotility
- oesophageal tumours
- benign oesophageal neoplasms
- malignant oesophageal neoplasms
- gastro-oesophageal reflux disease
- oesophageal stricture