Radiopaedia 2021 UPDATE Conference-only registration is now closed. Late registration for All-Access Pass and Free Country Pass holders ends this Friday - LEARN MORE

Glycogenic acanthosis

Glycogenic acanthosis is a benign finding on esophagography in elderly patients.

It most commonly occurs in patients >40 years of age and incidence and numbers of lesions increase by age. No gender predilection exists. Typically patients are asymptomatic. 

It occurs from a combination of cellular hyperplasia and increased cellular glycogen in squamous epithelial cells lining the esophagus. The esophageal mucosa is otherwise normal. It is not thought to be associated with gastro-esophageal reflux.

Severe forms are seen in patients with Cowden syndrome.

  • multiple small nodules and plaques measuring 2-10 mm
  • plaques are randomly distributed
  • often in the upper to mid thoracic esophagus
  • the appearance can appear similar to other forms of esophagitis like reflux esophagitis which however occur more distally and candida esophagitis which is more linear in configuration 
Oesophageal pathology

Article information

rID: 38493
Synonyms or Alternate Spellings:

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.