Glycogenic acanthosis is a benign finding on esophagography in elderly patients.
It most commonly occurs in patients >40 years of age and incidence and numbers of lesions increase by age. No gender predilection exists. Typically patients are asymptomatic.
It occurs from a combination of cellular hyperplasia and increased cellular glycogen in squamous epithelial cells lining the esophagus. The esophageal mucosa is otherwise normal. It is not thought to be associated with gastro-esophageal reflux.
Severe forms are seen in patients with Cowden syndrome.
- multiple small nodules and plaques measuring 2-10 mm
- plaques are randomly distributed
- often in the upper to mid thoracic esophagus
- the appearance can appear similar to other forms of esophagitis like reflux esophagitis which however occur more distally and candida esophagitis which is more linear in configuration
- 1. Tsai SJ, Lin CC, Chang CW et-al. Benign esophageal lesions: endoscopic and pathologic features. World J. Gastroenterol. 2015;21 (4): 1091-8. doi:10.3748/wjg.v21.i4.1091 - Free text at pubmed - Pubmed citation
- 2. Nazligül Y, Aslan M, Esen R et-al. Benign glycogenic acanthosis lesions of the esophagus. Turk J Gastroenterol. 2013;23 (3): 199-202. Pubmed citation
- 3. Rose D, Furth EE, Rubesin SE. Glycogenic acanthosis. AJR Am J Roentgenol. 1995;164 (1): 96. AJR Am J Roentgenol (citation) - Pubmed citation
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