Citation, DOI, disclosures and article data
At the time the article was created Matt A. Morgan had no recorded disclosures.View Matt A. Morgan's current disclosures
At the time the article was last revised Frank Gaillard had no recorded disclosures.View Frank Gaillard's current disclosures
Glycogenic acanthosis is a benign finding on esophagography in elderly patients.
It most commonly occurs in patients >40 years of age and incidence and numbers of lesions increase by age. No gender predilection exists. Typically patients are asymptomatic.
It occurs from a combination of cellular hyperplasia and increased cellular glycogen in squamous epithelial cells lining the esophagus. The esophageal mucosa is otherwise normal. It is not thought to be associated with gastro-esophageal reflux.
Severe forms are seen in patients with Cowden syndrome.
- multiple small nodules and plaques measuring 2-10 mm
- plaques are randomly distributed
- often in the upper to mid thoracic esophagus
- the appearance can appear similar to other forms of esophagitis like reflux esophagitis which however occur more distally and candida esophagitis which is more linear in configuration
- 1. Tsai SJ, Lin CC, Chang CW et-al. Benign esophageal lesions: endoscopic and pathologic features. World J. Gastroenterol. 2015;21 (4): 1091-8. doi:10.3748/wjg.v21.i4.1091 - Free text at pubmed - Pubmed citation
- 2. Nazligül Y, Aslan M, Esen R et-al. Benign glycogenic acanthosis lesions of the esophagus. Turk J Gastroenterol. 2013;23 (3): 199-202. Pubmed citation
- 3. Rose D, Furth EE, Rubesin SE. Glycogenic acanthosis. AJR Am J Roentgenol. 1995;164 (1): 96. AJR Am J Roentgenol (citation) - Pubmed citation