GM2 gangliosidoses

Last revised by Dr Daniel J Bell on 09 Jun 2020

The GM2 gangliosidoses are a small group of three closely-related rare genetic conditions, all due to a deficiency of beta-hexosaminidase, an enzyme vital for the metabolism of GM2 gangliosides in lysosomes, especially important in the brain. The GM2 gangliosidoses form a subgroup of the lysosomal storage diseases.

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.