The gold standard (occasionally, erroneously, called the golden standard) is the term used in medicine for the test (imaging, blood test, biopsy, etc.) that is felt to be the current best for diagnosis of a particular condition. The gold standard for any specific disease is not set in stone and can change over time. It is against the gold standard that any new diagnostic test is compared.
The term is also employed more widely in medicine to refer to the best procedure, treatment, research methodology etc. For example, randomized controlled trials are the gold standard for evaluating the efficacy of new drugs 3.
History and etymology
The gold standard in economics refers to the historical system by which countries' currencies were valued to a stated physical amount of gold 1,3.
The first use of gold standard in the medical literature is thought to be a review article in the Lancet in 1975 3.
- 1. Claassen JAHR. The gold standard: not a golden standard. BMJ. 2005 May 14;330(7500):1121. PubMed Central PMCID: PMC557893.
- 2. Cardoso JR, Pereira LM, Iversen MD, Ramos AL. What is gold standard and what is ground truth?. (2014) Dental press journal of orthodontics. 19 (5): 27-30. doi:10.1590/2176-9451.19.5.027-030.ebo - Pubmed
- 3. Jones DS, Podolsky SH. The history and fate of the gold standard. (2015) Lancet (London, England). 385 (9977): 1502-3. doi:10.1016/S0140-6736(15)60742-5 - Pubmed
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- gold standard
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- sine qua non
- subclinical disease
- fluid collection
- granulation tissue