Gradenigo syndrome
Updates to Article Attributes
Gradenigo syndrome consists of the triad of:
-
suppurative otitis media with persistent
otorrheaotorrhoea and ear pain - abducens nerve palsy, secondary to involvement of the nerve as it passes through Dorello canal
- retro-orbital pain, or pain in the cutaneous distribution of the frontal and maxillary divisions of the trigeminal nerve, due to extension of inflammation into Meckel cave
Additionally patients tend to suffer intractable otorrhoea and pain in the region of the ophthalmic and maxillary branches of the trigeminal nerve.
Epidemiology
The incidence of this condition has significantly diminished since the antibiotic era, however, it is still occasionally observed, and often diagnosed late due to the subtlety of the symptoms 4.
Clinical presentation
The classic constellation of symptoms is described above, however, it is important to note that not all patients will present with the complete triad. In addition, other symptoms may include:
- involvement of the facial nerve and vestibulocochlear nerve 5
- photophobia
- fever
- excessive lacrimation
Further spread of infection may give rise to complications, including:
- intracranial abscess
- meningitis
- skull base involvement
- parapharyngeal abscess
- prevertebral abscess
Pathology
The syndrome typically arises as a consequence of chronic suppurative otitis media spreading to the petrous apex of the temporal bone, resulting in petrous apicitis. The trigeminal ganglion and abducens nerve lie in close proximity to the petrous apex, within Meckel cave and the Dorello canal respectively. Extradural inflammation due to petrous apicitis may therefore affect these nearby structures and give rise to the classical symptoms of Gradenigo syndrome 4. Common pathogens are Pseudomonas and Enterococcus spp.
Radiographic features
CT
Findings may include bone destruction, opacification of the petromastoid air cells, and intracranial abscess formation 4.
MRI
MRI can aid differentiation between neoplasia and infection, as well as being superior to CT in demonstrating the inflammatory changes of petrous apicitis 5.
Treatment and prognosis
The mainstay of treatment is antibiotic therapy 4. Rare cases may require surgical intervention.
History and etymology
ItGradenigo syndrome was first described in 1907 by Giuseppe Conte Gradenigo (1859-1926), an Italian otolaryngologist 2,3.
-<a href="/articles/otitis-media">suppurative otitis media</a> with persistent otorrhea and ear pain</li>- +<a href="/articles/otitis-media">suppurative otitis media</a> with persistent otorrhoea and ear pain</li>
-<li>retro-orbital pain, or pain in the cutaneous distribution of the frontal and maxillary divisions of the <a href="/articles/trigeminal-nerve">trigeminal nerve</a>, due to extension of inflammation into <a href="/articles/meckel-cave-1">Meckel cave</a>- +<li>retro-orbital pain, or pain in the cutaneous distribution of the frontal and maxillary divisions of the <a href="/articles/trigeminal-nerve">trigeminal nerve</a>, due to extension of inflammation into <a href="/articles/meckels-cave-3">Meckel cave</a>
-<li>fever</li>-<li>excessive lacrimation</li>- +<li><a title="Fever" href="/articles/pyrexia">fever</a></li>
- +<li><a title="Epiphora" href="/articles/epiphora">excessive lacrimation</a></li>
-<li>intracranial abscess</li>- +<li><a title="Cerebral abscess" href="/articles/brain-abscess-1">intracranial abscess</a></li>
-<li>prevertebral abscess</li>-</ul><h4>Pathology</h4><p>The syndrome typically arises as a consequence of chronic suppurative otitis media spreading to the <a href="/articles/petrous-apex">petrous apex</a> of the temporal bone, resulting in <a href="/articles/petrous-apicitis">petrous apicitis</a>. The <a href="/articles/trigeminal-ganglion">trigeminal ganglion</a> and abducens nerve lie in close proximity to the petrous apex, within Meckel cave and the Dorello canal respectively. Extradural inflammation due to petrous apicitis may therefore affect these nearby structures and give rise to the classical symptoms of Gradenigo syndrome <sup>4</sup>. Common pathogens are <em>Pseudomonas </em>and <em>Enterococcus spp. </em></p><h4>Radiographic features</h4><h5>CT</h5><p>Findings may include bone destruction, opacification of the petromastoid air cells, and intracranial abscess formation <sup>4</sup>.</p><h5>MRI</h5><p>MRI can aid differentiation between neoplasia and infection, as well as being superior to CT in demonstrating the inflammatory changes of petrous apicitis <sup>5</sup>. </p><h4>Treatment and prognosis</h4><p>The mainstay of treatment is antibiotic therapy <sup>4</sup>. Rare cases may require surgical intervention.</p><h4>History and etymology</h4><p>It was first described in 1907 by <strong>Giuseppe Conte Gradenigo </strong>(1859-1926), Italian otolaryngologist <sup>2,3</sup>. </p>- +<li><a title="prevertebral abscess" href="/articles/prevertebral-abscess">prevertebral abscess</a></li>
- +</ul><h4>Pathology</h4><p>The syndrome typically arises as a consequence of chronic suppurative otitis media spreading to the <a href="/articles/petrous-apex">petrous apex</a> of the temporal bone, resulting in <a href="/articles/petrous-apicitis">petrous apicitis</a>. The <a href="/articles/trigeminal-ganglion">trigeminal ganglion</a> and abducens nerve lie in close proximity to the petrous apex, within <a title="Meckel cave" href="/articles/meckels-cave-3">Meckel cave</a> and the <a title="Dorello canal" href="/articles/dorello-canal">Dorello canal</a> respectively. Extradural inflammation due to petrous apicitis may therefore affect these nearby structures and give rise to the classical symptoms of Gradenigo syndrome <sup>4</sup>. Common pathogens are <em>Pseudomonas </em>and <em>Enterococcus </em>spp. </p><h4>Radiographic features</h4><h5>CT</h5><p>Findings may include bone destruction, opacification of the petromastoid air cells, and intracranial abscess formation <sup>4</sup>.</p><h5>MRI</h5><p>MRI can aid differentiation between neoplasia and infection, as well as being superior to CT in demonstrating the inflammatory changes of petrous apicitis <sup>5</sup>. </p><h4>Treatment and prognosis</h4><p>The mainstay of treatment is antibiotic therapy <sup>4</sup>. Rare cases may require surgical intervention.</p><h4>History and etymology</h4><p>Gradenigo syndrome was first described in 1907 by <strong>Giuseppe Conte Gradenigo </strong>(1859-1926), an Italian otolaryngologist <sup>2,3</sup>. </p>