Graft versus host disease (pulmonary manifestations)

Last revised by Hoe Han Guan on 18 Apr 2023

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Guan H, Di Muzio B, et al. Graft versus host disease (pulmonary manifestations). Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-25181

DOI:

https://doi.org/10.53347/rID-25181

Permalink:

https://radiopaedia.org/articles/25181

rID:

25181

Article created:

10 Oct 2013, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

18 Apr 2023, Hoe Han Guan ◉

Disclosures:

At the time the article was last revised Hoe Han Guan had no financial relationships to ineligible companies to disclose.

View Hoe Han Guan's current disclosures

Revisions:

10 times, by 8 contributors - see full revision history and disclosures

Systems:

Chest, Haematology

Tags:

cases

Synonyms:

Thoracic manifestations of graft versus host disease
Thoracic manifestations of GvHD
Thoracic GvHD
Pulmonary manifestations of graft versus host disease

Pulmonary graft versus host disease (GvHD) is one of the thoracic manifestations that can complicate hematopoietic stem cell transplantation. Pulmonary GvHD can be broadly divided into acute and chronic disease ^1-4:

acute pulmonary GvHD
- pulmonary involvement is rare
- the median time of onset of respiratory symptoms is around five months
- reported radiological features include ³
  - mild perihilar or diffuse interstitial fibrosis
  - pulmonary cysts
  - pulmonary nodules
chronic pulmonary GvHD
- usually presents as a bronchiolitis obliterans and/or organizing pneumonia
- pulmonary fibrosis (non-classifiable interstitial pneumonia) ⁶

References

1. Wah TM, Moss HA, Robertson RJ et-al. Pulmonary complications following bone marrow transplantation. Br J Radiol. 2003;76 (906): 373-9. Br J Radiol (full text) - doi:10.1259/bjr/66835905 - Pubmed citation
2. Leung AN, Gosselin MV, Napper CH et-al. Pulmonary infections after bone marrow transplantation: clinical and radiographic findings. Radiology. 1999;210 (3): 699-710. Pubmed citation
3. Franquet T, Müller NL, Lee KS et-al. High-resolution CT and pathologic findings of noninfectious pulmonary complications after hematopoietic stem cell transplantation. AJR Am J Roentgenol. 2005;184 (2): 629-37. doi:10.2214/ajr.184.2.01840629 - Pubmed citation
4. Liu QF, Luo XD, Ning J et-al. Association between acute graft versus host disease and lung injury after allogeneic haematopoietic stem cell transplantation. Hematology. 2009;14 (2): 63-72. doi:10.1179/102453309X385142 - Pubmed citation
5. Coy DL, Ormazabal A, Godwin JD et-al. Imaging evaluation of pulmonary and abdominal complications following hematopoietic stem cell transplantation. Radiographics. 2005;25 (2): 305-17. doi:10.1148/rg.252045037 - Pubmed citation
6. Peña E, Souza CA, Escuissato DL, Gomes MM, Allan D, Tay J, Dennie CJ. Noninfectious pulmonary complications after hematopoietic stem cell transplantation: practical approach to imaging diagnosis. (2014) Radiographics : a review publication of the Radiological Society of North America, Inc. 34 (3): 663-83. doi:10.1148/rg.343135080 - Pubmed
7. Inyoung Song, Chin A Yi, Joungho Han, Dong Hwan Kim, Kyung Soo Lee, Tae Sung Kim, Myung Jin Chung. CT Findings of Late-Onset Noninfectious Pulmonary Complications in Patients With Pathologically Proven Graft-Versus-Host Disease After Allogeneic Stem Cell Transplant. (2012) American Journal of Roentgenology. doi:10.2214/AJR.11.7165