Granular cell tumors (GrCTs) are uncommon soft tissue tumors with the vast majority being benign (approximately 0.5-2.0% have been reported as malignant).
They have are reported at various sites which include
- breast - granular cell tumor of the breast
- soft palate 2
- pituitary - granular cell tumor of the pituitary region
They are often classified as benign or malignant using the Fanburg-Smith criteria (especially for soft tissue lesion) 3,4.
- 1. Blacksin MF, White LM, Hameed M, Kandel R, Patterson FR, Benevenia J. Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation. (2005) Skeletal radiology. 34 (10): 625-31. doi:10.1007/s00256-005-0925-8 - Pubmed
- 2. Rita Boulos, Kathlyn Marsot-Dupuch, Philippe De Saint-Maur, Bernard Meyer, Patrice Tran Ba Huy. Granular Cell Tumor of the Palate: A Case Report. (2002) American Journal of Neuroradiology. 23 (5): 850. Pubmed
- 3. Singh VA, Gunasagaran J, Pailoor J. Granular cell tumour: malignant or benign?. (2015) Singapore medical journal. 56 (9): 513-7. doi:10.11622/smedj.2015136 - Pubmed
- 4. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. (1998) The American journal of surgical pathology. 22 (7): 779-94. Pubmed