Granuloma
Updates to Article Attributes
Granulomas are organised conglomerates of histiocytes, a specialised white blood cell 1. They form by the process of granulomatous inflammation, which is a specific type of chronic inflammation that occurs following cellular injury as a response to the mediators that are released. A broad range of insults, including infections, autoimmune, foreign bodies, allergens and neoplastic disease, may trigger the formation of granulomas. This inflammatory response is seen at all ages and in all body tissues.
They may also coalesce to form multinucleated giant cells. Identification and classification of the granulomatous inflammation pattern can be helpful in narrowing a clinical differential diagnosis.
-<p><strong>Granulomas </strong>are organised conglomerates of <a title="Histiocytes" href="/articles/histiocytes">histiocytes</a>, a specialised <a title="White cell" href="/articles/white-blood-cell">white blood cell</a> <sup>1</sup>. They form by the process of <strong>granulomatous inflammation,</strong> which is a specific type of chronic inflammation that occurs following cellular injury as a response to the mediators that are released. A broad range of insults, including infections, autoimmune, foreign bodies, allergens and neoplastic disease, may trigger the formation of granulomas. This inflammatory response is seen at all ages and in all body tissues.</p><p> </p><p> They may also coalesce to form multinucleated giant cells. Identification and classification of the granulomatous inflammation pattern can be helpful in narrowing a clinical differential diagnosis.</p>- +<p><strong>Granulomas </strong>are organised conglomerates of <a href="/articles/histiocytes">histiocytes</a>, a specialised <a href="/articles/white-blood-cell">white blood cell</a> <sup>1</sup>. They form by the process of <strong>granulomatous inflammation,</strong> which is a specific type of chronic inflammation that occurs following cellular injury as a response to the mediators that are released. A broad range of insults, including infections, autoimmune, foreign bodies, allergens and neoplastic disease, may trigger the formation of granulomas. This inflammatory response is seen at all ages and in all body tissues.</p>
References changed:
- 1. Shah KK, Pritt BS, Alexander MP. Histopathologic review of granulomatous inflammation. (2017) Journal of clinical tuberculosis and other mycobacterial diseases. 7: 1-12. <a href="https://doi.org/10.1016/j.jctube.2017.02.001">doi:10.1016/j.jctube.2017.02.001</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/31723695">Pubmed</a> <span class="ref_v4"></span>
- 2. Mukhopadhyay S, Farver CF, Vaszar LT, Dempsey OJ, Popper HH, Mani H, Capelozzi VL, Fukuoka J, Kerr KM, Zeren EH, Iyer VK, Tanaka T, Narde I, Nomikos A, Gumurdulu D, Arava S, Zander DS, Tazelaar HD. Causes of pulmonary granulomas: a retrospective study of 500 cases from seven countries. (2012) Journal of clinical pathology. 65 (1): 51-7. <a href="https://doi.org/10.1136/jclinpath-2011-200336">doi:10.1136/jclinpath-2011-200336</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/22011444">Pubmed</a> <span class="ref_v4"></span>
Sections changed:
- Pathology
Tags changed:
- cases
- reference needed