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Granulomatosis with polyangiitis (breast manifestations)

Breast involvement in granulomatosis with polyangiitis is seen in patients with avid systemic manifestations. 

Clinically they can mimic carcinoma as a palpable, tender mass.

Granulomatosis with polyangiitis (or formerly known as Wegeners granulomatosis) is a necrotizing granulomatous vasculitis which is characterized by necrotizing granulomatous inflammation, small and medium-sized vessel vasculitis, and focal necrotizing glomerulonephritis.

The commonest areas of involvement are the respiratory tracts and kidneys, but the disease can affect any organ system.

May be seen as an irregular and high-density mass.

The treatment for granulomatosis with polyangiitis depends on the severity of the disease. Severe disease can be treated with corticosteroids and cyclophosphamide. For less severe disease, the treatment may be corticosteroids and methotrexate. Approximately half of patients with granulomatosis with polyangiitis may experience a relapse within 2 years of stopping treatment.

Breast imaging and pathology
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Article information

rID: 25692
System: Breast
Tag: refs, cases
Synonyms or Alternate Spellings:
  • Wegener’s granulomatosis of the breast
  • Breast involvement in Wegeners granulomatosis
  • Breast involvement in granulomatosis with polyangiitis

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