Granulomatosis with polyangiitis (renal manifestations)
The renal manifestations of granulomatosis with polyangiitis (GPA) (previously known as Wegener granulomatosis) are occult on imaging, especially when compared to the pulmonary changes. Approximately half of GPA patients have kidney disease at presentation. Granulomatosis with polyangiitis is a multisystem systemic necrotizing non-caseating granulomatous vasculitis affecting small to medium-sized arteries, capillaries and veins.
Reduced renal function, proteinuria and haematuria.
GPA affects the kidneys with the development of necrotising glomerulonephritis in ~60% (range 39-80%) of patients.
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