Granulomatous lymphocytic interstitial lung disease

Granulomatous-lymphocytic interstitial lung disease (GLILD) is a relatively recent term given to describe non-infectious, diffuse lung disease complications that have been reported to traditionally develop in common variable immunodeficiency (CVID) patients. Some papers also report the occurrence of these conditions with primary immunodeficiency states such as 6


They exhibit both granulomatous and lymphoproliferative histologic patterns consisting of:

Treatment and prognosis

Immunosuppressive therapy (e.g. rituximab) has been successfully used in the treatment of GLILD. The presence of GLILD in association with CVID confers a poorer prognosis and also carries an increased risk of lymphoproliferative disorders.

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Article information

rID: 64047
System: Chest
Synonyms or Alternate Spellings:
  • Granulomatous-lymphocytic interstitial lung disease (GLILD)

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