Gullo syndrome

Gullo syndrome, also known as benign pancreatic hyperenzymaemia, is characterized by the abnormal elevation of the serum levels of most or all of the pancreatic enzymes without any evidence of underlying pancreatic pathology. All other laboratory assays and imaging studies are unremarkable.

Individuals are asymptomatic since they lack any underlying pancreatic disease.

Its cause remains unknown. It has been described in both sporadic and familial forms.

By definition of the disease amylase and lipase levels will be elevated three times the upper limit of normal for a period of over one year. Variations in the levels of the enzymes can occur from day-to-day.

Benign pancreatic hyperenzymaemia is a diagnosis of exclusion and by definition all imaging of the pancreas, including the ductal system, will be normal.

The syndrome was first described by Lucio Gullo (1938-2009) 4, a renowned Italian pancreatologist, in 1996 3.

Share article

Article information

rID: 63804
Section: Syndromes
Tag: stub
Synonyms or Alternate Spellings:
  • Sporadic benign pancreatic hyperenzymaemia
  • Familial benign pancreatic hyperenzymaemia
  • Benign pancreatic hyperenzymaemia
  • Sporadic benign pancreatic hyperenzymemia
  • Familial benign pancreatic hyperenzymemia
  • Benign pancreatic hyperenzymemia

Support Radiopaedia and see fewer ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.