Haemochromatosis (skeletal manifestations)

Haemochromatosis is a systemic disease which affects many organs systems (see the main hemochromatosis article), including the joints, characterised by haemosiderin and calcium pyrophosphate deposition resulting in:

  • chondrocalcinosis: particularly knees and triangular fibrocartilage
  • arthropathy
    • symmetrical loss of joint space, subchondral cysts 
    • similar appearances/distribution as CPPD
    • most commonly hands (MCP, carpal, PIP) with the characteristic beak-like osteophytes projecting from radial ends of 2nd and 3rd metacarpals
      • more extensive involvement from the second to the fifth MCP and radial hook-like/drooping osteophytes are more characteristic than in CPPD 3

    • can also affect the knee, hip, and elbow  
  • generalised osteoporosis (~25%) or osteopaenia (~40%) 4

Differential diagnosis

See also

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Article Information

rID: 9721
Tags: cases, refs
Synonyms or Alternate Spellings:
  • Skeletal manifestations of haemochromatosis
  • Skeletal manifestations of hemochromatosis
  • Musculoskeletal manifestations of haemochromatosis
  • Musculoskeletal manifestations of hemochromatosis

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