Haemolytic anaemia

Haemolytic anaemia is a form of anaemia where red blood cells (RBCs) are destroyed either intravascularly or extravascularly.

Clinical presentation

The patient presents with anaemia and jaundice. Diagnosis is based on several laboratory parameters 1:

  • reticulocytosis
  • increased unconjugated bilirubin
  • increased lactate dehydrogenase
  • decreased haptoglobin

Pathology

With excessive destruction of RBCs, there is compensatory erythroid hyperplasia in the bone marrow, resulting in increased production of erythroid precursors (reticulocytosis).

Causes
Hereditary

Haemolytic anaemia can be due to defects in:

Acquired
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Article Information

rID: 31667
System: Haematology
Section: Gamuts
Tag: cases
Synonyms or Alternate Spellings:
  • Haemolytic anaemias
  • Hemolytic anaemia
  • Hamolytic anaemias

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