Hemorrhage on MRI

Hemorrhage on MRI has highly variable imaging characteristics that depend on both the age of the blood, the type of hemoglobin present (oxy- deoxy- or met-), on whether or not the red blood cell walls are intact and the specifics of the MRI sequence. Although MRI is often thought of as not being sensitive to acute hemorrhage, this is not, in fact, true particularly with more modern sequences 5,7.

The appearance of hemorrhage will, however, be different at different times and is not perfectly stereotyped, as such caution should be exercised in precisely aging hemorrhages. 

The factors that affect the appearance of hemorrhage on MRI vary according to the sequence. The oxygenation state of hemoglobin and the location of either contained within red blood cells or diffused in the extracellular space have a tremendous effect on the imaging effects of blood. The three hemoglobin states to be considered are oxyhemoglobin, deoxyhemoglobin and methemoglobin. 

Oxyhemoglobin, accounting for 95% of hemoglobin in arterial blood and 70% in venous blood, is only weakly diamagnetic, having little T2* and only mildly shortening T1 relaxation time 2,6. This is the result of heme iron is in ferrous form (Fe2+) and has no unpaired electrons 2

Deoxyhemoglobin, in contrast, having lost oxygen has four unpaired electrons and is strongly paramagnetic and results in substantial signal loss on T2* weighted sequences, such as susceptibility weighted imaging, and blooming artefact 2

Methemoglobin results from oxidative denaturation of the heme molecule to the ferric (Fe3+) form has five unpaired electrons is also strongly paramagnetic 2


Oxyhemoglobin and deoxyhemoglobin little effect on T1 signal. The presence of blood proteins results in intermediate T1 signal in hyperacute and acute hemorrhages. 

T2* weighted sequences, such as susceptibility weighted imaging and gradient echo are primarily affected by the hemoglobin oxygenation state and whether or not cell lysis has occurred 2

While contained within red blood cells, resulting in uneven distribution of paramagnetic effects, both deoxyhemoglobin and methemoglobin result in signal loss. Once the cells lyse and methemoglobin is distributed evenly throughout the clot, the local magnetic field distortion is also lost and T2 signal loss fades 2

Eventually hemosiderin and ferritin (both paramagnetic) are then ingested by monocytes and macrophages and result once more in unevenly distributed paramagenic effects and signal loss 2


In general, five stages of hematoma evolution are recognised:

  1. hyperacute (<1day)
    • intracellular oxyhemoglobin
    • isointense on T1
    • isointense to hyperintense on T2
  2. acute (1 to 3 days)
    • intracellular deoxyhemoglobin
    • T2 signal intensity drops (T2 shortening)
    • T1 remains intermediate-to-low
  3. early subacute (3 to 7 days)
    • intracellular methemoglobin
    • T1 signal gradually increases (T1 shortening) to become hyperintense
  4. late subacute (7 to 14-28 days)
    • extracellular methemoglobin: over the next few weeks, as cells break down, extracellular methemoglobin leads to an increase in T2 signal 
  5. chronic (>14-28 days)
    • periphery
      • intracellular hemosiderin
      • low on both T1 and T2
    • center
      • extracellular haemichromes
      • isointense on T1, hyperintense on T2

Remembering these may be facilitated by this aging blood on MRI mnemonic.

  • extracranial blood products age differently from intracranial blood products, and extracranial hematomas often have a heterogeneous appearance, confounding attempts at reliably dating the age of an extracranial hemorrhage 3,4
  • subacute and chronic blood appears hypointense and blooms on MRI T2* weighted sequences (e.g. susceptibility weighted imaging (SWI))
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Article information

rID: 6671
Section: Approach
Tag: mri
Synonyms or Alternate Spellings:
  • Aging blood on MRI

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Cases and figures

  • Figure 1: sequence of aging blood on MRI
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  • Case 1: hyperacute
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  • Figure 2: MRI and CT characteristics
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  • Case 3: subacute sudural hematoma
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  • MRI of the brain ...
    Case 4: acute on chronic
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  • Case 5: chronic
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