Hemosiderosis is a general term referring to the accumulation of hemosiderin, which particularly occurs in the reticuloendothelial system (RES) and does not cause organ damage.


Some causes include:

  • frequent transfusion 
    • mainly depositional siderosis in RES
    • if >40 units transfused: then may cause hemochromatosis (non-RES iron deposition)
  • high erythrogenic requirements (hemolytic anemiamyelodysplasia)
    • mainly depositional siderosis in RES from transfusion
    • increased duodenal iron absorption may lead to hemochromatosis (non-RES iron deposition)
  • bantu siderosis: rare cause in Africa due to iron-laden locally brewed beer 

See also

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Article information

rID: 9723
System: Haematology
Section: Gamuts
Tag: cases, refs
Synonyms or Alternate Spellings:
  • Hemosiderosis

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