HIV-associated neurocognitive disorders
Last revised by Tom Foster on 28 Apr 2023
Citation, DOI, disclosures and article data
Citation:
Di Muzio B, Foster T, Ranchod A, et al. HIV-associated neurocognitive disorders. Reference article, Radiopaedia.org (Accessed on 24 Apr 2024) https://doi.org/10.53347/rID-38006
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38006
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Disclosures:
At the time the article was created Bruno Di Muzio had no recorded disclosures.
View Bruno Di Muzio's current disclosures
Last revised:
28 Apr 2023,
Tom Foster ◉
Disclosures:
At the time the article was last revised Tom Foster had no financial relationships to ineligible companies to disclose.
View Tom Foster's current disclosures
Revisions:
8 times, by
7 contributors -
see full revision history and disclosures
Systems:
Synonyms:
- HIV associated neurocognitive disorders
- HIV-associated neurocognitive disorders (HANDs)
- HIV-associated neurocognitive disorders (HAND)
HIV-associated neurocognitive disorders (HANDs), is a term that emerged from an international conference in 2006 1, and corresponds to a group of clinical syndromes related to the HIV infection in the cells of the nervous system expressing different degrees of impairment of cognition and associated functioning. They are part of neuroAIDS.
Three different clinical conditions have been defined 1-3:
- asymptomatic neurocognitive impairment: characterised by impairment in cognitive function clinically diagnosed, however the everyday functioning is not affected
- mild neurocognitive disorder: characterised by impairment in cognitive function clinically diagnosed and mild interference in everyday functioning
- HIV-associated dementia (HAD): characterised by marked impairment in cognitive function which significantly limits abilities to function in daily work, home and social activities. It was previously referred as AIDS dementia complex and is the only condition which demonstrates clear recognisable features of HIV encephalopathy on MRI.
References
- 1. Antinori A, Arendt G, Becker JT et-al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology. 2007;69 (18): 1789-99. doi:10.1212/01.WNL.0000287431.88658.8b - Free text at pubmed - Pubmed citation
- 2. Clifford DB, Ances BM. HIV-associated neurocognitive disorder. Lancet Infect Dis. 2013;13 (11): 976-86. doi:10.1016/S1473-3099(13)70269-X - Free text at pubmed - Pubmed citation
- 3. Gannon P, Khan MZ, Kolson DL. Current understanding of HIV-associated neurocognitive disorders pathogenesis. Curr. Opin. Neurol. 2011;24 (3): 275-83. doi:10.1097/WCO.0b013e32834695fb - Free text at pubmed - Pubmed citation
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