Heidenhain variant of sporadic Creutzfeldt-Jakob disease

Last revised by Rohit Sharma on 25 Dec 2022

The Heidenhain variant of sporadic Creutzfeldt-Jakob disease is a distinct clinical manifestation of a number of molecular subtypes (MM1 and MM2C) dominated by pure visual disturbances early in the course of the disease 1.

Radiographic features

MRI

MRI predictably correlates with prominent early occipital involvement 1.

History and etymology

The phenotype was first described by Adolf Heidenhain, German neurologist, in 1929 3

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