Hepatic amyloidosis

Hepatic amyloidosis is an uncommon manifestation of amyloidosis.

It can be primary or secondary and it typically occurs as diffuse infiltration 2.

There is amyloid deposition in liver parenchyma which occurs along the sinusoids within the space of Disse, or in blood vessel walls. Hepatocytes can be markedly compressed by extensive accumulation of amyloid and they may atrophy or nearly disappear.

In advanced cases with massive infiltration, the liver is enlarged with a rubbery elastic consistency, and it may show 'lardaceous liver' appearance .

Ultrasound

Non specific and may show heterogeneous hepatic echotexture 3.

CT

There can be hepatomegaly with decreased hepatic attenuation 2. Some calcifcation may be present.

MRI liver
  • T1: has increased signal though the liver 1,3
  • T2: little change 3

For CT appearances of decreased hepatic attenuation: see causes of decreased hepatic attenuation.

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Article Information

rID: 23451
Tag: cases
Synonyms or Alternate Spellings:
  • Liver amyloidosis
  • Amyoidosis of the liver
  • Amyoidosis involving the liver

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