Hepatic amyloidosis is an uncommon manifestation of amyloidosis.
It can be primary or secondary and it typically occurs as diffuse infiltration 2.
There is amyloid deposition in liver parenchyma which occurs along the sinusoids within the space of Disse, or in blood vessel walls. Hepatocytes can be markedly compressed by extensive accumulation of amyloid and they may atrophy or nearly disappear.
In advanced cases with massive infiltration, the liver is enlarged with a rubbery elastic consistency, and it may show 'lardaceous liver' appearance.
Non-specific and may show heterogeneous hepatic echotexture 3.
There can be hepatomegaly with decreased hepatic attenuation 2. Some calcification may be present.
- T1: has increased signal through the liver 1,3
- T2: little change 3
For CT appearances of decreased hepatic attenuation: see causes of decreased hepatic attenuation.
- 1. Shin YM. Hepatic amyloidosis. Korean J Hepatol. 01;17 (1): 80-3. doi:10.3350/kjhep.2011.17.1.80 - Free text at pubmed - Pubmed citation
- 2. Georgiades CS, Neyman EG, Barish MA et-al. Amyloidosis: review and CT manifestations. Radiographics. 2004;24 (2): 405-16. Radiographics (full text) - doi:10.1148/rg.242035114 - Pubmed citation
- 3. Son RC, Chang JC, Choi JH. Primary hepatic amyloidosis: report of an unusual case presenting as a mass. Korean J Radiol. 01;12 (3): 382-5. doi:10.3348/kjr.2011.12.3.382 - Free text at pubmed - Pubmed citation
- 4. Møller JM, Santoni-Rugiu E, Chabanova E et-al. Magnetic resonance imaging with liver-specific contrast agent in primary amyloidosis and intrahepatic cholestasis. Acta Radiol. 2007;48 (2): 145-9. Acta Radiol (abstract) - doi:10.1080/02841850601128959 - Pubmed citation
- 5. Suzuki S, Takizawa K, Nakajima Y et-al. CT findings in hepatic and splenic amyloidosis. J Comput Assist Tomogr. 1986;10 (2): 332-4. Pubmed citation
- 6. Marmolya G, Karlins NL, Petrelli M et-al. Unusual computed tomography findings in hepatic amyloidosis. Clin Imaging. 1990;14 (3): 248-50. Pubmed citation