Hepatitis B virus
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At the time the article was created Matt A. Morgan had no recorded disclosures.View Matt A. Morgan's current disclosures
At the time the article was last revised Jeremy Jones had no recorded disclosures.View Jeremy Jones's current disclosures
Hepatitis B virus (HBV) is a circular DNA virus endemic in many parts of the world. It is a risk factor for the development of hepatocellular carcinoma (HCC).
Route of transmission
The most common route of transmission is regionally-dependent. In endemic areas, vertical transmission from mother to child is more common. In other areas, contaminated needles, blood products, and unprotected sex is more common.
- genotype A: sub-Saharan Africa
- genotype B: Japan and East Asia
- genotype C: China, Korea, Japan, Southeast Asia
- most closely associated with HCC 2
- genotype D: Eastern Europe, North Africa, Russia, Middle East, India
- genotype E: West Africa
- genotypes F, G, H: Central and South America
Treatment and prognosis
Vaccination programs have been effective in many parts of the world to decrease the incidence of disease.
Patients with chronic hepatitis B may benefit from a hepatocellular carcinoma screening program.
Acute infection with the hepatitis B virus may result in acute hepatitis.