Hepatosplenomegaly

Last revised by Dr Rohit Sharma on 26 Jun 2022

Hepatosplenomegaly is simply the simultaneous presence of a pathologically-enlarged liver (hepatomegaly) and spleen (splenomegaly).

Pathology

Etiology
Infection

Many infections can produce a mild concurrent enlargement of the liver and spleen. This list is by no means exhaustive.

Malignancy
Hematological
Storage diseases/metabolic/infiltrative disorders
Connective tissue disorders
Others

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Cases and figures

  • Case 1: thalassemia
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  • Case 2: lymphoma
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  • Case 3: Wolman disease
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  • Case 4: tuberculosis
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  • Case 5: hereditary spherocytosis
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  • Case 6: sickle cell disease
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  • Case 7: autoimmune hemolytic anemia
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  • Case 8: chronic myeloid leukemia
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