HER-2 mutations in lung cancer

Human epidermal growth factor receptor 2 (HER-2) mutations may be detected in approximately 3% of lung adenocarcinomas 1.

Radiographic features

CT

Early studies have attempted to at lung adenocarcinomas with HER2 gene mutation which have suggested HER2-mutant tumors exhibit more aggressive features in general and tend to 

  • exhibit a locally-invasive behavior compared with KRAS-mutant tumors 3
  • show preponderance for pleural retractions compared with KRAS- and EGFR-mutant tumors 3
  • present with greater nodal metastatic spread compared KRAS-mutant tumors 3.

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Article information

rID: 69172
System: Chest, Oncology
Section: Pathology
Synonyms or Alternate Spellings:
  • Human epidermal growth factor receptor 2 mutations in lung cancer
  • Human epidermal growth factor receptor 2 (HER-2) mutations in lung cancer

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